- a platform for effective drug discovery
We developed the patented F.I.R.S.T.™. screening tool to serve as an important technology tool for both our own drug development and for our external partners. The platform allows for smarter development of novel antibody therapeutics since new candidates can be detected without detailed knowledge about the target protein of the antibodies. This unique approach offers the advantage of simultaneously identifying disease-associated targets and antibodies which bind to them. The method is based on simultaneous investigation of antibody binding to both diseased and healthy tissue in order to specifically select those antibodies and target structures that are unique for diseased tissue in terms of binding and expression. In a high-throughput functional screening, antibodies are then selected based on their ability to kill primary cancer cells through differentially expressed, cancer cell-associated surface receptors.