At BioInvent, we combine deep immunological understanding with target agnostic screening (the target structure is identified only when functional activity is verified) to identify the clinically most relevant targets and antibodies for cancer immunotherapy. Patient tissue, alongside our F.I.R.S.T™ technology platform and the human antibody library n-CoDeR®, are cornerstones in this process.
The unique development tool F.I.R.S.T™, where patient material is the foundation throughout the development process, simultaneously identifies the clinically most relevant targets in a disease model and matching antibodies. The proprietary antibody library n-CoDeR® contains antibodies that bind specifically and strongly to their targets.
TUMOR-ASSOCIATED MYELOID CELLS (TAM)
Myeloid cells are a key part of our innate, non-specific, immune system but can also be “hijacked” by tumors to support the growth and spread of cancer. Antibody-mediated “reprogramming” of immunosuppressive tumor-associated myeloid cells (TAMs) to become effector cells that can help to eliminate cancer cells is an attractive therapy concept and a field of research where BioInvent and its partners are at the forefront.
BioInvent has so far received USD 6.6 million in milestone payments besides research funding for an R&D collaboration with Pfizer 2017-2020 on the selection of TAM targets. Pfizer has selected its targets and BioInvent is eligble for potential future development milestones in excess of USD 100 million if one antibody is developed through to commercialization, and up to double digit royalties on future sales.
REGULATORY T CELLS (TREGS)
Normally, Tregs suppress undesirable activation of the immune system, but unfortunately also enable tumors to evade the body’s immune system in cancer. There are many publications showing a clear correlation between the number of Tregs in cancer patients and poor prognosis. BioInvent is developing antibodies specifically targeting regulatory T cells and tumor associated myeloid cells, both of which are strongly immunosuppressive, with the aim to deplete or re-educate these cells for enhanced immunemediated cancer rejection.